题目：Periodicity and Synchronization in Malaria Infection with Immune Response

--- With an Introduction of Research by some Nobel Laureates in Medicine or Physiology

疟疾传染免疫应答的周期性与同步性 ---- 若干诺贝尔医学或生理奖工作简介

报告人：阮世贵教授

时间：7月2日3:00-4:00

地点：管研楼1208

摘要：

On October 3, 2011, three scientists (Bruce A. Beutler, Jules A. Hoffmann and Ralph M. Steinman) won this year’s Nobel Prizes in Medicine or Physiology for their discoveries on how the innate and adaptive phases of the immune response are activated and thereby provide novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases. In this talk I’ll use malaria as an example to explain how both innate immunity and adaptive immunity fight against malaria infection and to model the within-host dynamics of malaria infection with immune response. For the ODE model consisted of healthy red blood cells, infected red blood cells, malaria parasitemia, and immune effectors, conditions on the existence and stability of both infection equilibria are given and it is shown that the model can exhibit periodic oscillations. For the age-structured malaria model of infected red blood cells (Rouzine and McKenzie, Proc Natl Acad Sci USA, 2003) it is also shown that Hopf bifurcation can occur by using the replication rate as the bifurcation parameter. Both mathematical analysis and numerical simulations confirm the observation of Kwiatkowski and Nowak (Proc Natl Acad Sci USA,1991) that synchronization with regular periodic oscillations (of period 48 h) occurs in malaria infection with modest replication rates. 

报告人简介：

阮士贵教授于1992年获加拿大阿尔伯特大学应用数学博士学位，1992-1994年在菲尔兹数学所和麦克马斯特大学做博士后， 其后担任加拿大道尔毫斯大学数学系助理教授、副教授，现为美国迈阿密大学数学系教授。其主要研究领域是动力系统和微分方程及其在生物和医学中的应用，在非线性发展方程的中心流型理论，非局部反应扩散方程的行波解，抗生素耐药性细菌的医院感染的数学建模，传染病与癌症的数学建模，生物系统的多参数分支分析等方向作了一系列重要工作。被SCI收录100多篇文章，受到了国内外同行的关注与大量引用，担任了国内外一些重要核心学术期刊的编委。作为项目负责人获得美国国家卫生研究院和美国国家科学基金多项资助。在20 多个国际学术会议上作过大会特邀报告，在60多个国际学术会议上作过邀请报告，在世界各地100多所大学作过学术报告，组织过20 多次国际学术会议，编辑了10 本论文集。对一些在中国流行的传染病（如非典、乙型肝炎、血吸虫感染、狂犬病等）的数学建模、数据模拟和理论分析作了一系列开创性工作，这些工作不但填补这方面的科研空白，而且对理解和控制这些传染病在我国的流行和传播有非常重要的现实指导意义。

主办单位：0029cc金沙贵宾会

国家数学与交叉科学中心合肥分中心

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